Rx.com semaglutide cost & review
By Sofia Mendez, Patient Education EditorUpdated
No auto-renewal, a named pharmacy and one price at every dose, if you read past the banner.
On this page
Is Rx.com worth it? The short answer
Our verdict
Rx.com gets two big things right: nothing renews or ships until you confirm each refill, and it names the pharmacy that dispenses your medication. The price holds at every dose. The banner's lifetime rate, though, is a full year paid in one charge. Budget on the month-to-month rate from the semaglutide page, and confirm your state first.
- Good for: You want a plan that asks before each refill instead of billing itself
- Look elsewhere if: You want an oral route or a brand-name option
Rx.com at a glance
Price, as published
$175/mo
$175 a month for compounded semaglutide, month to month, the same at every dose from 0.25 mg to 2.4 mg, with the provider visit, injection supplies and shipping stated as included.
Full pricing details
Prepaid it is $165 a month over three months ($495), $146 over six ($875) and $99 over twelve ($1,188 in one payment). The banner's "$99/mo FOR LIFE" is that twelve-month prepay.
Pricing model
Flat at every dose
Consult
Included
Labs
Not required
Dietitian
Not included
Pharmacy
1 pharmacy named
Who makes your medication
Manifest Pharmacy
Greer, SC
Rx.com names its pharmacy, so you can look it up before you start.
Where this comes from →What six months of Rx.com costs you
Semaglutide is long-term, so here is what six months adds up to, clinician visits included.
Month 1
$175
Months 2 to 6, each
$175
Six-month total
$1,050
Paying month to month; longer plans in the price above can lower this. Prices change, so check before you pay.
What it does well, and what to watch
What we like
- "No automatic renewals" is printed under the plan card itself rather than buried in terms
- Names the dispensing pharmacy with a full street address, and the provider network, on the same site as the price
- One flat price at every dose, with the visit, supplies and shipping stated as included and no membership fee
- A provider who declines to prescribe does not charge for medication
What to watch
- "$99/mo FOR LIFE" is the twelve-month plan paid as one $1,188 charge; month to month it is $175
- The FAQ says 49 states served (all but Alaska) while the banner on the same site says all 50
- An older program page on the same site still lists different, higher monthly prices
- Injection only — no oral route and no brand-name option
Who Rx.com suits, and who should look elsewhere
A good fit if
- You want a plan that asks before each refill instead of billing itself
- You want to know which pharmacy fills the prescription before you pay
- You expect to titrate and want the price to hold at every dose
Look elsewhere if
- You want an oral route or a brand-name option
- You'd take the lifetime banner at face value without reading the plan options
- You live in Alaska, the one state it doesn't serve
How Rx.com works, start to finish
Rx.com's online GLP-1 program is run by Rx Platform LLC.
More about how it works
The full ladder sits on the semaglutide page before any intake, and the site names who dispenses: Manifest Pharmacy, 1018 S. Batesville Road, Greer, SC 29650, with MD Integrations named as the provider network. A licensed provider decides whether treatment is appropriate, usually within 24 hours, and if not you are not charged for medication. Plans do not renew on their own: nothing ships or is charged until you confirm each refill.
- Pick semaglutide and a plan length, then check out in about two minutes.
- Complete a health questionnaire and upload a photo ID; some states add a short video visit.
- A licensed provider in your state reviews it, usually within 24 hours.
- If you're not approved, you get a full refund.
- Once approved, the pharmacy ships within two to four business days; delivery takes three to seven.
- Before each refill your care team checks in, and nothing ships until you confirm.
What Rx.com includes in the price
- Online provider visit and follow-ups
- Medication at any prescribed dose, same price
- Syringes, alcohol pads and a dosing guide
- Discreet, tracked shipping
- Unlimited messaging with your care team
- Ongoing check-ins and dose adjustments
For a compounded prescription, the guide to milligrams and syringe units sets out what to confirm with the dispensing pharmacist about your own vial and measuring device.
If you want to cancel or get a refund
Plans don't renew on their own: before each refill your care team checks in, and nothing is charged until you confirm. You can pause or cancel from your account at any time with no fees. Medication can't be returned once it ships, so those sales are final.
Questions people ask about Rx.com
Does Rx.com auto-renew my GLP-1 plan?
No. Rx.com says plans don't renew automatically, and refills are sent only after you check in with your care team and confirm.
Is Rx.com's lifetime price real?
It's the twelve-month plan, paid as one charge up front. Month to month costs more; all four plan lengths are on the semaglutide page and in the price box above.
Who dispenses Rx.com prescriptions?
Manifest Pharmacy in Greer, South Carolina, named on the site with its street address. MD Integrations is named as the provider network.
Is Rx.com available in Alaska?
No. Its FAQ says it serves 49 states, all except Alaska, even though the site banner says all 50.
Will my Rx.com bill rise as I titrate?
No. Rx.com says it never charges by strength, so your price stays the same from the starting dose up to 2.4 mg. Only the plan length changes it.
If Rx.com isn't the right fit
Close to Rx.com, but each does better on the thing Rx.com does least well.
States its pharmacy type
Sprout Health
PartnerSays what kind of pharmacy makes it, which Rx.com doesn't.
$149 per 4 weeks
FDA warning letter · September 2025Clearer pricing
bmiMD
PartnerIts headline price is closer to what you'll pay each month.
$159/mo
More care included
CoreAge Rx
Featured partnerClinician visits and dietitian support come in the price.
$99/mo
Partners pay us a commission if you start care through our link. How we make money
Before you pay for anything
Semaglutide is a prescription medicine, and the compounded version is not the same regulated product as Wegovy or Ozempic. Go into your visit with real numbers and these reads:
How Rx.com stacks up against the others
Two minutes of comparing could save you money, or confirm Rx.com is the right pick.
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