Interactive tool · Weight-loss projection
How much weight might Wegovy help you lose?
Enter your current weight and this tool projects where you might be at about week 68 on semaglutide 2.4 mg, using the −14.9% average from the STEP-1 trial — plus a milestone trajectory across the 16-week dose titration. It shows a population average, not a promise: real results vary a lot from person to person.
Read before you use this
This is an educational projection, not a prediction of your result, and not medical advice. The number it shows is the average total-body-weight reduction observed in the STEP-1 trial of semaglutide 2.4 mg (−14.9% at week 68) — applied to your weight as simple arithmetic. Individual results varied enormously in that trial: some people lost far more, some far less, and weight often returns after stopping. It is not a dosing tool and says nothing about whether semaglutide is right for you. Semaglutide is prescription-only after a clinician's review — treat this as a starting point for a conversation with a licensed provider, not a plan.
STEP-1 average projection · semaglutide 2.4 mg · ~68 weeks
Enter your current weight above to see a STEP-1 average projection.
Projection only, based on the STEP-1 trial average for semaglutide 2.4 mg. It is not a prediction of your result and not medical or dosing advice. Talk to a licensed clinician about whether semaglutide is appropriate for you.
How it is calculated. Projected week-68 weight = your starting weight × (1 − 0.149), using the STEP-1 mean total-body-weight reduction of −14.9% for semaglutide 2.4 mg (Wilding et al., N Engl J Med 2021; PMID 33567185). Each milestone weight = start − (start × 14.9% × that milestone's fraction of the endpoint). Worked example: 200 lb × 0.851 = 170.2 lb at week 68 (a 29.8 lb loss); at the end of titration (week 16, ~35% of the endpoint) ≈ 189.6 lb. Week 0 and week 68 are trial anchors; the in-between curve is an illustrative front-loaded shape.
Questions people ask
- How much weight does this project I'll lose on Wegovy?
- It projects the STEP-1 trial average: a 14.9% reduction in total body weight at about week 68 on semaglutide 2.4 mg. So a 220 lb starting weight projects to roughly 187 lb (a ~33 lb loss). That's the population average from the trial, not a prediction of your personal result.
- Where does the 14.9% figure come from?
- From STEP-1, the pivotal 68-week randomized trial of once-weekly semaglutide 2.4 mg for weight management (Wilding JPH, et al., New England Journal of Medicine, 2021; PMID 33567185). Participants lost on average 14.9% of their body weight at week 68, versus 2.4% on placebo.
- Will I actually lose this much?
- Maybe more, maybe less. 14.9% is an average — in STEP-1 individual results ranged widely. Roughly a third of participants lost 20% or more of their body weight, while others lost little. Your result depends on dose tolerance, diet, activity, genetics, and staying on treatment. This tool deliberately shows the average, not a personalized prediction, and it is not a substitute for advice from a clinician.
- What is the milestone trajectory?
- STEP-1 reports the week-68 endpoint, not a published week-by-week curve, so the trajectory shows a typical front-loaded shape — loss accruing faster once you reach the higher maintenance dose, then tapering as weight plateaus. Only week 0 and week 68 are trial-anchored (marked ●); the points in between are an illustrative model, clearly labelled, to show roughly when loss tends to happen across the 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg titration.
- Does weight come back after stopping?
- Often, yes. Follow-up of semaglutide trial participants found much of the lost weight returned within about a year of stopping the medication. This calculator models on-treatment weight at ~68 weeks only; it does not project what happens after you stop. Discuss long-term plans with your prescriber.
- Is this medical advice?
- No. It is an educational arithmetic projection of a published trial average. It does not tell you whether semaglutide is right for you, what dose to take, or what your result will be. Semaglutide is prescription-only after clinician review — talk to a licensed provider.
Put the number in context
A projected number is the easy part. How fast it comes off, what it costs, and whether it's worth it for you are the parts that matter — read these next:
This calculator is informational and not medical advice. It performs simple arithmetic (projected weight = starting weight × (1 − 0.149)) using the STEP-1 trial average for semaglutide 2.4 mg (Wilding et al., N Engl J Med 2021; PMID 33567185) and makes no prediction about your individual outcome. Only the week-0 and week-68 points of the trajectory are trial-anchored; the curve between them is an illustrative model. Semaglutide is available by prescription after clinician review. Talk to a licensed provider about whether the medication is appropriate for you.